Presenting Clinical and Laboratory Data of Childhood Acute Lymphoblastic Leukemia

نویسندگان

  • Ali Pahloosye
  • Atef Atefi
  • Azam Sadat Hashemi
  • Seid Jalil Mirmohammadi
چکیده مقاله:

Abstract Background Leukemia is the most prevalent childhood cancer and Acute Lymphoblastic Leukemia (ALL) constitutes 75% of all cases. The most frequent presenting symptoms are fever, weight loss and pallor. Early detection of clinical symptoms positively affects timely diagnosis. The objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune phenotypes and prognostic factors in children with diagnosis of ALL. Materials and Methods We performed a prospective follow-up study of 100 patients aged 1-16 years diagnosed with ALL, admitted to Shahid Sadoughi hospital pediatrics ward from March 2006 to February 2010. Demographic and biochemical data were obtained from their medical record. Data were analyzed using SAS 9.1.3 software. Results The mean of patients’ ages was 9 years. Complete blood cell count was abnormal in all of the patients, and pancytopenia was detected in 27% of the patients. Of all the patients, 25% had abnormal white blood cell (WBC) count at presentation, 37% had leucopenia and 38% had leukocytosis. WBC count was above 50,000/mm³ in 22% of cases. Anemia was detected in 85% of the patients. There was no significant sex difference, but a significant age difference existed among patients (p < .05). According to flowcytometry results, 61% of patients had T-cell and 39% had B-cell immune phenotype. The frequency of undesirable prognostic factors was more in T-cell than the B-cell group, but this difference was only significant for male patients (p<0.05). The most common presenting symptoms were systemic symptoms, which comprised of lethargy and malaise in 81%, anorexia in 72%, pallor in 69% and fever in 59% of cases. Musculoskeletal system was the most common system involved. Conclusion In our study, T-cell immune phenotypes comprised the most frequent form of ALL in children. The presence of male sex and high WBC count could make its outcome worse. However, on time chemotherapy could alter the outcome of these patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

presenting clinical and laboratory data of childhood acute lymphoblastic leukemia

abstract background leukemia is the most prevalent childhood cancer and acute lymphoblastic leukemia (all) constitutes 75% of all cases. the most frequent presenting symptoms are fever, weight loss and pallor. early detection of clinical symptoms positively affects timely diagnosis. the objectives of the present study were to assess frequency of presenting symptoms, laboratory data, immune phen...

متن کامل

Clinical and laboratory biology of childhood acute lymphoblastic leukemia.

A cute lymphoblastic leukemia (ALL) is the most common malignancy of childhood, accounting for 25% of cancers diagnosed in children and adolescents aged 1-19 years, and translating to approximately 3000 new cases diagnosed in the US yearly. Progress in therapy for childhood ALL has been dramatic, with event-free survival (EFS,meaning that patients do not relapse or succumb to side effects) impr...

متن کامل

Correlations of clinical and laboratory data for prognosis in childhood acute lymphoblastic leukemia.

Correlation of 24 different clinical and laboratory measures was performed for a calculation of the prognosis in 65 children with newly diagnosed acute lymphoblastic leukemia (ALL). The hematologic as well as genetic parameters were studied at the time of diagnosis. It was shown that the initial blast count in peripheral blood is the most important risk factor for the prognosis of ALL. Cytogene...

متن کامل

Childhood Acute Lymphoblastic Leukemia.

The cure rate for childhood acute lymphoblastic leukemia (ALL) now exceeds 70%. This success has been achieved in part by improvements in the biologic characterization of newly diagnosed patients. Modern treatment protocols rely on this information to tailor therapy to a patient's risk of relapse. Patients with favorable genetic features, such as hyperdiploidy or the TEL-AML1 fusion, can be tre...

متن کامل

Childhood Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is recognized as a fast-developing cancer originated from blood-progenitor cells. Blasts cells are immature cells which generate white blood cells (leukocytes), and it is the malignancy of the blast cells which lead to leukemias. The bone marrow is gradually filled up with these blasts and as a result, the production of healthy blood cells will be damaged. Mal...

متن کامل

Acute Disseminated Encephalomyelitis in Childhood; Epidemiologic, Clinical, and Laboratory Features

Background: Acute disseminated encephalomyelitis (ADEM), which occurs spontaneously or after systemic viral infection and vaccination mostly affects children. This study aims at describing the epidemiologic, clinical, neuroimaging, laboratory features, treatment and outcome in children who diagnosed as having ADEM and admitted in a referral center in Tehran. Methods: This descriptive prospectiv...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 1  شماره 3

صفحات  71- 77

تاریخ انتشار 2011-09

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023